Juventus hope to have Leo Bonucci available, as Paulo Dybala seems set to start against Barcelona, spearheaded by Lionel Messi but without Gerard Pique.
The match kicks off at 20.00 UK time.
Coach Andrea Pirlo must cope without injured captain Giorgio Chiellini and talisman Cristiano Ronaldo, who is still positive for coronavirus.
The Old Lady will evaluate Bonucci until the last minute and if the Italy international will be available, he is expected to start in a back-three with Danilo and Merih Demiral.
Pirlo admitted the alternative is to play four at the back, expectedly with Juan Cuadrado and Frabotta as full-backs.
Paulo Dybala should start with Alvaro Morata up front, as Portuguese superstar Ronaldo tested positive for COVID-19 yesterday.
Barcelona lost Pique to a red card in the 5-2 win against Ferencvaros and coach Ronald Koeman is expected to replace him with Araujo.
The Catalans are likely to make changes from the XI that lost the El Clasico against Real Madrid last weekend, and Miralem Pjanic could get the go ahead against his former teammates.
Ousmane Dembele and Antoine Griezmann could also start in Turin.
Juventus (probable): Szczesny; Danilo, Bonucci, Demiral; Cuadrado, Bentancur, Rabiot, Chiesa; Ramsey; Dybala, Morata
Barcelona (probable): Neto; Sergi Roberto, Araujo, Lenglet, Jordi Alba; Pjanic, De Jong; Dembele, Griezmann, Ansu Fati; Messi
Referee: Makkelie (HOL)