Roma should have Chris Smalling back from injury against CSKA Sofia and Borja Mayoral will replace Edin Dzeko in the Europa League.
The match kicks off at 20.00 UK time.
The Giallorossi coach Paulo Fonseca revealed Smalling returns to action in the European Cup and that Dzeko will be given a breather.
Pau Lopez should start in goal, with Federico Fazio and Marash Kumbulla completing the back-three with Smalling.
Bruno Peres and Leonardo Spinazzola should play out wide, while Bryan Cristante and Gonzalo Villar plays in the middle.
Carles Perez and Henrikh Mkhitaryan are expected to play behind the Spanish striker.
CSKA arrive at the Olimpico with three coaches, as Stamen Belchev was sacked after a run of poor results.
The trident of coaches, Daniel Morales, Kiril Dinchev and Krassimir Chomakov will most likely turn up in a 4-2-3-1 in Rome, with Ali Sowe leading the line ahead of Amos Youga, Jerome Sinclair and Younousse Sankhare in the attacking trident.
Roma (probable): Pau Lopez; Fazio, Smalling, Kumbulla; Bruno Peres, Cristante, Villar, Spinazzola; Carles Perez, Mkhitaryan; Mayoral
CSKA Sofia (probable): Busatto; Vion, Antov, Mattheij, Mazikou; Tiago Rodrigues, Youga; Sinclair, Sankhare, Yomov; Sowe
Referee: Kulbakov (BLR)