Zlatan Ibrahimovic leads out Milan against Sparta Prague in the Europa League, with Brahim Diaz, Sando Tonali and Diogo Dalot.
It kicks off at 17.55 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Rossoneri dropped points for the first time this season in Monday night’s 3-3 thriller with Roma, which was overshadowed by controversial refereeing decisions.
Theo Hernandez, Franck Kessie, Alexis Saelemaekers, Rafael Leao and Hakan Calhanoglu are rested following that match, but there is no time off for 38-year-old hitman Ibrahimovic.
He is supported by the trio of Samu Castillejo, Rade Krunic and Brahim Diaz, with Sandro Tonalli stepping into midfield.
Diogo Dalot comes in at left-back for his second game in the Milan jersey following a loan from Manchester United.
Gianluigi Donnarumma and Jens Petter Hauge are out of action after contracting COVID-19, with Mattia Gabbia, Mateo Musacchio and Leo Duarte still injured.
Sparta Prague has some familiar faces to Serie A viewers, including former Bologna winger Ladislav Krejci and ex-Lazio striker Libor Kozak.
However, Kozak is initially on the bench in favour of Lukas Julis with Krejci and captain Borek Dockal.
David Hankco, Lukas Stetina, Ondrej Celustka and Dominik Plechaty are injured.
Adam Hlozek is a late absentee with a foot injury and is only on the bench.
Milan: Tatarusanu; Calabria, Kjaer, Romagnoli, Dalot; Tonali, Bennacer; Castillejo, Krunic, Brahim Diaz; Ibrahimovic
Milan bench: Moleri, A Donnarumma, Calhanoglu, Conti, Leao, Hernandez, Kalulu, Maldini, Colombo, Duarte, Saelemaekers, Kessie
Sparta Prague: Heca; Sacek, Celustka, Lischka, Hanousek; Pavelka, Travnik, Vindheim; Dockal, Krejci, Julis
Sparta Prague bench: Nita, Kotek, Plechaty, Moberg-Karlsson, Kozac, Hlozek, Plavsic, Polidar, Wiesner, Karabec, Vitik, Patrak
Ref: Ozkahya (TUR)