Inter are forced to reshuffle without Romelu Lukaku and Alexis Sanchez, so Ivan Perisic and Christian Eriksen step in with Lautaro Martinez against Gervinho’s Parma.
It kicks off at 17.00 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri are forced into changes after disappointing results in Serie A and the Champions League, as Lukaku has a muscular problem and is also in doubt for the upcoming Real Madrid clash.
Alexis Sanchez, Stefano Sensi, Milan Skriniar – who today finally tested negative for COVID-19 – and Matias Vecino are also out of action.
Antonio Conte therefore sticks with his 3-4-1-2 formation, but uses Eriksen as the trequartista and pushes Perisic into a more advanced striker’s role.
It’s a new back three too, with Stefan de Vrij, Andrea Ranocchia and Aleksandar Kolarov, with Roberto Gagliardini returning from COVID-19 to give Arturo Vidal a rest.
Matteo Darmian made the move from Parma to Inter on deadline day and starts against his old club.
Parma are still struggling with their COVID-19 outbreak and over the last 24 hours released two statements confirming four players who had previously tested positive have now been reinfected.
That can happen when they were asymptomatic and the viral load was low, as not enough antibodies were created to provide immunity.
The Ducali have not named the infected players, but Bruno Alves, Matteo Scozzarella, Vincent Laurini and Hans Nicolussi Caviglia are absent.
Gervinho had been on the verge of a move to Inter this summer, while Nerazzurri-owned Yann Karamoh is on the bench.
Andreas Cornelius leads the attack with Juraj Kucka in support.
Inter: Handanovic; De Vrij, Ranocchia, Kolarov; Hakimi, Barella, Gagliardini, Darmian; Eriksen; Lautaro Martinez, Perisic
Parma: Sepe; Iacoponi, Pezzella, Balogh, Gagliolo; Grassi, Hernani, Kurtic; Kucka; Cornelius, Gervinho