Sampdoria go for a fourth straight victory with Fabio Quagliarella and Gaston Ramirez, while rivals Genoa look to Goran Pandev and Gianluca Scamacca in the Derby della Lanterna.
It kicks off at Marassi at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
Sampdoria go for a fourth straight victory with Fabio Quagliarella and Gaston Ramirez, while rivals Genoa look to Goran Pandev and Gianluca Scamacca in the Derby della Lanterna.
It kicks off at Marassi at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Blucerchiati go into this clash as favourites, having won their last three Serie A matches, including against Champions League teams Lazio and Atalanta.
Manolo Gabbiadini is the only absentee, so Gaston Ramirez supports veteran hitman Quagliarella, with impressive youngsters Mikkel Damsgaard and Morten Thorsby in midfield.
Antonio Candreva returns to the squad, but is only fit enough for a place on the bench.
Genoa have finally got all their players back after the COVID-19 outbreak ruled out 17 last month, although Stefano Sturaro, Francesco Cassata, Davide Zappacosta and Eldor Shomurodov are injured.
Italy Under-21 international Gianluca Scamacca is chosen as the centre-forward, backed by Goran Pandev and Miha Zajc, as Genoa move to a 4-3-2-1 formation.
Domenico Criscito is back in business too following his Coronavirus experience.
Sampdoria: Audero; Bereszynski, Yoshida, Tonelli, Augello; Ekdal, Thorsby, Jankto, Damsgaard; Ramirez, Quagliarella
Sampdoria bench: Ravaglia, Letica, Silva, Verre, Keita, Colley, Askildsen, Regini, La Gumina, Ferrari, Leris, Candreva
Genoa: Perin; Biraschi, Goldaniga, C Zapata, Criscito; Lerager, Badelj, Rovella; Pandev, Zajc; Scamacca
Genoa bench: Marchetti, Paleari, Behrami, Bani, Ghiglione, Radovanovic, Destro, Melegoni, Pjaca, Masiello, Parigini, Pellegrini
Ref: La Penna