Atalanta rely on Papu Gomez, Duvan Zapata and Luis Muriel as they welcome Premier League holders Liverpool with Mohamed Salah and Diogo Jota.
It kicks off at the Gewiss Stadium in Bergamo at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Real Madrid-Inter on the LIVEBLOG.
Atalanta rely on Papu Gomez, Duvan Zapata and Luis Muriel as they welcome Premier League holders Liverpool with Mohamed Salah and Diogo Jota.
It kicks off at the Gewiss Stadium in Bergamo at 20.00 GMT.
This ought to be a fascinating clash of styles between Gian Piero Gasperini and Jurgen Klopp, as well as a head-to-head for the top of the group, as Atalanta are on four points and Liverpool six.
La Dea reached the quarter-finals last season in their first ever Champions League campaign, minutes away from eliminating PSG, while the Reds won the tournament in 2019.
Both have injury problems to deal with, as Atalanta miss Marten de Roon, Robin Gosens and Mattia Caldara, while Hans Hateboer and Cristian Romero required late fitness tests.
There had been doubts Hateboer would start, but he is in the XI with Johan Mojica on the left.
It’s an all-attack approach with Papu Gomez supporting Colombian pair Muriel and Duvan Zapata.
Liverpool are forced into some changes too, missing Virgil van Dijk, Fabinho and Alex Oxlade-Chamberlain, while Thiago Alcantara and Konstantinos Tsimikas were injury doubts.
Because Thiago doesn’t make it and Roberto Firmino is rested ahead of the Manchester City match, Diogo Jota steps into the team and Sadio Mane becomes a centre-forward with ex-Roma star Mohamed Salah.
Former Roma goalkeeper Alisson Becker recently returned from injury, but James Milner and Joel Matip are also rested.
Atalanta: Sportiello; Toloi, Palomino, Djimsiti; Hateboer, Pasalic, Freuler, Mojica; Gomez; Muriel, Duvan Zapata
Atalanta bench: Rossi, Gollini, Lammers, Romero, Malinovskyi, Depaoli, Pessina, Ruggeri, Scalvini, Miranchuk, Ilicic, Traore
Liverpool: Alisson; Alexander-Arnold, Gomez, R Williams, Robertson; Henderson, Wijnaldum, Jones; Salah, Mane, Jota
Liverpool bench: Adrian, Kelleher, Milner, Keita, Firmino, Minamino, Tsimikas, Shaqiri, Origi, Matip, Cain, N Williams
Ref: Hategan (ROU)