Roma should continue to rotate in the Europa League with Borja Mayoral and Pau Lopez back in the line-up when CFR Cluj arrive at the Olimpico.
The match kicks off at 17.55 UK time.
The Giallorossi coach Paulo Fonseca hope to bounce back from a 0-0 draw with CSKA Sofia last time and should start with Pau Lopez in goal, who has kept one clean sheet in two games.
The shot stopper has not started in Serie A this term, but seems a regular in Europe, and the same goes for Borja Mayoral – who has only played once in Serie A but both games in the Europa League.
The rotation might also lead to Federico Fazi in defence, with Bruno Peres at right and Gonzalo Villar in the middle.
Cluj arrive in complete chaos, as coach Dan Petrescu is ready to leave and confirmed he was going to resign after the match against the Giallorossi.
The 52-year-old, who is in his second career spell with the club, started the campaign in the Europa League with a 2-0 win over CSKA Sofia and 1-1 against Young Boys.
Roma (probable): Pau Lopez; Ibanez, Fazio, Kumbulla; Bruno Peres, Cristante, Villar, Spinazzola; Pellegrini, Mkhitaryan; Borja Mayoral
Cluj (probable): Balradean; Susic, Manea, Ciobotariu, Camora; Djokovic, Hoban; Rondon, Paun, Daec; Debeljuh
Referee: Jug (SLO)