Zlatan Ibrahimovic, Brahim Diaz and Sandro Tonali start as Milan aim to keep their perfect Europa League record against Lille.
It kicks off at 20.00 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Rossoneri went through three preliminary rounds to reach the tournament and won both their opening two Group H games too.
By hosting second-placed Lille, who are on four points, they have the opportunity to create a huge gap at the top.
Ibrahimovic is therefore not rested, despite missing a penalty last time out against Sparta Prague, with support from Brahim Diaz, Samu Castillejo and Rade Krunic.
Davide Calabria is out with a muscular problem, so Diogo Dalot moves to right-back with Theo Hernandez on the left.
Tonali and Franck Kessie form the midfield, resting Ismael Bennacer, but Gianluigi Donnarumma is also back following COVID-19.
Rafael Leao and Simon Kjaer have both played for Lille in the past.
Ligue 1 side Lille do not have ex-Genoa defender Adama Soumaoro, as he hasn’t recovered from injury, so Jose Fonte partners Sven Botman in the back four.
Bobokary Soumaré is only on the bench along with usual captain Andre, while Yusuf Yazici and Jonathan David are the front two.
Milan: G Donnarumma; Dalot, Kjaer, Romagnoli, Theo Hernandez; Kessie, Tonali; Castillejo, Krunic, Brahim; Ibrahimovic
Milan bench: A Donnarumma, Tatarusanu, Conti, Duarte, Gabbia, Kalulu, Bennacer, Calhanoglu, Hauge, Leao, Maldini, Rebic
Lille: Maignan; Zeki Celik, Fonte, Botman, Bradaric; Renato Sanches, Xeka, Bamba, Ikone; Yazici, David
Lille bench: Karnezis, Chevalier, Tiago Djalo, Burak Yilmaz, Lihadji, Andre, Weah, Soumare, Soumaoro, Pied, Niasse, Mandava
Ref: Frankowski (POL)