Juventus are forced to completely revamp their defence with Matthijs de Ligt’s first appearance of the season, while Cagliari also have to make changes.
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The Bianconeri have struggled so far in Serie A under new coach Andrea Pirlo, having drawn four of their last six games on the pitch.
He is forced to transform his defence, because Giorgio Chiellini, Leonardo Bonucci and Aaron Ramsey are injured, so De Ligt is rushed into his comeback.
This is the Dutchman’s first appearance since he has surgery to stabilise a dislocated shoulder in August.
It’s also a rare start for Turkish international Merih Demiral, with Danilo completing the defence.
Dejan Kulusevski gets the nod rather than Federico Chiesa, while Paulo Dybala is again benched for Alvaro Morata and Cristiano Ronaldo.
Cagliari had problems on international duty too, as Diego Godin returned from Uruguay with COVID-19 and his teammate Nahitan Nandez is self-isolating as a precaution.
Paolo Faragò, Charalampos Lykogiannis and Luca Ceppitelli are also out of action for coach Eusebio Di Francesco.
Joao Pedro has found the net in each of his last five Serie A games and wants to make it six as he again starts behind Giovanni Simeone.
Adam Ounas, on loan from Napoli, gets the nod with Italy Under-21 internationals Gabriele Zappa and Alessandro Tripaldelli.
Cagliari beat Juventus 2-0 in the most recent meeting in July, but they haven’t won in Turin since 2009.
Juventus: Buffon; Cuadrado, Demiral, De Ligt, Danilo; Kulusevski, Arthur, Rabiot, Bernardeschi; Morata, Ronaldo
Cagliari: Cragno; Pisacane, Klavan, Walukiewicz, Tripaldelli; Marin, Rog; Zappa, Joao Pedro, Ounas; Simeone