Alexis Sanchez partners Romelu Lukaku rather than Lautaro Martinez for Inter, while Andrea Belotti pulls out of a Torino side ravaged by COVID.
It kicks off at San Siro at 14.00 GMT.
The Nerazzurri need to get back on track after stuttering both domestically and in the Champions League, but are also wary of fatigue after the break for international duty.
This is why Lautaro Martinez is rested in favour of Alexis Sanchez, but the problems are above all in midfield, where Marcelo Brozovic and Aleksandar Kolarov caught COVID, with Stefano Sensi and Matias Vecino injured.
Torino have been affected even more by Coronavirus, as coach Marco Giampaolo is self-isolating at home, with four players also ruled out by the pandemic.
Although they’ve not been named, they’re believed to be Amer Gojak, Sasa Lukic, Mergim Vojvoda and Samir Ujkani.
Simone Zaza is back in the squad after several weeks out with injury, but was meant to be on the bench, until Andrea Belotti pulled out during the warm-up.
Simone Verdi starts in what looks like a 3-5-2 formation, very unusual for Giampaolo.
The Granata rely more than ever on their hitman, as Belotti has six goals in seven Serie A appearances this season, so losing him is a heavy blow.
Inter: Handanovic; D’Ambrosio, Ranocchia, A Bastoni; Hakimi, Gagliardini, Vidal, Young; Barella; R Lukaku, Alexis Sanchez
Torino: Sirigu; Bremer, Lyanco, Nkoulou; Singo, Meite, Rincon, Linetty, Ansaldi; Verdi, Zaza
Ref: La Penna