Paulo Dybala returns to the starting line-up with Cristiano Ronaldo, while the Juventus defence is down to the bare bones against Ferencvaros.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
The Bianconeri lost heavily to Barcelona, so are second in their Champions League group with six points, but still comfortably ahead of Dynamo Kiev and Ferencvaros on one.
It means they could qualify for the Round of 16 tonight if they win and Barcelona don’t lose to Dynamo Kiev.
They won 4-1 in Hungary with an Alvaro Morata brace, but the Spain international is benched tonight in favour of Dybala and Ronaldo.
Leonardo Bonucci and Giorgio Chiellini are still injured, joined on the treatment table by Merih Demiral and Gianluigi Buffon.
Matthijs de Ligt therefore is the only available centre-back with Danilo, using Juan Cuadrado and Alex Sandro on the flanks.
Federico Bernardeschi and Weston McKennie take the wide roles around Arthur and Rodrigo Bentancur.
Ferencvaros make the trip without defenders Endre Botka, who is self-isolating due to COVID contact, and Eldar Civic, but adopt a very defensive five-man defence.
Juventus: Szczesny; Cuadrado, Danilo, De Ligt, Alex Sandro; McKennie, Bentancur, Arthur, Bernardeschi; Dybala, Ronaldo
Juventus bench: Pinsoglio, Israel, Buffon, Ramsey, Morata, Chiesa, Rabiot, Dragusin, Frabotta, Portanova, Kulusevski
Ferencvaros: Dibusz; G Lovrencsics, Blazic, Frimpong, Dvali, Heister; Siger, Somalia; Zubkov, Uzuni, Nguen
Ferencvaros bench: Szecsi, Ori, Kharatin, Kovacevic, Mak, Botka, Baturina, Csontos, Boli, Isael, Laidouni
Ref: Siebert (GER)