Inter rely on Lautaro Martinez, Romelu Lukaku and Arturo Vidal for the must-win Champions League match with Real Madrid, who miss Karim Benzema and Sergio Ramos, so change tactics.
It kicks off at San Siro at 20.00 GMT.
The Nerazzurri desperately need a victory or risk not only going out of the Champions League in the opening round, but also out of Europe altogether.
They are currently bottom of the group with just two points, though it is extremely tight, as Borussia Monchengladbach lead with five, then Shakhtar Donetsk and Real Madrid on four.
This clash has not been played at the Stadio Giuseppe Meazza since November 25, 1998, with Inter winning 3-1 thanks to Ivan Zamorano and a Roberto Baggio brace.
Marcelo Brozovic and Aleksandar Kolarov are still out with COVID-19, with Matias Vecino injured and Stefano Sensi only fit for the bench.
Vidal therefore gets the nod as trequartista this time behind Lukaku and Lautaro Martinez, with Nicolò Barella taking a deeper role.
As ever, there’s no room for Christian Eriksen in Antonio Conte’s vision.
Real Madrid have struggled badly too this season, losing the opener to Shakhtar Donetsk, fighting back for 2-2 at Gladbach and scraping a 3-2 win over Inter.
The injury crisis is piling up, as Benzema, Sergio Ramos, Federico Valverde, Eder Militao, Luka Jovic and Alvaro Odriozola are out of action.
Mariano Diaz is therefore the only real alternative upfront, but there’s a change of tactics to 4-2-3-1 with Martin Odegaard, Lucas Vazquez and Eden Hazard supporting him.
Nacho steps into the defence and Ferland Mendy is again preferred to Marcelo at left-back.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Gagliardini, Young; Vidal; Lukaku, Lautaro Martinez
Inter bench: Stankovic, Radu, Alexis Sanchez, Sensi, Ranocchia, Perisic, Eriksen, D’Ambrosio, Darmian, Nainggolan,
Real Madrid: Courtois; Carvajal, Varane, Nacho, Mendy; Modric, Kroos; Lucas Vazquez, Odegaard, E Hazard; Mariano Diaz
Real Madrid bench: Lunin, Altube, Asensio, Marcelo, Casemiro, Vinicius Junior, Isco, Rodrygo, Chust, Hugo Duro
Ref: Taylor (ENG)