Sassuolo hope Domenico Berardi and Jeremie Boga can cause another upset in the head-to-head for second place with Inter, who rest Romelu Lukaku.
It kicks off at the Mapei Stadium in Reggio-Emilia at 14.00 GMT.
The Neroverdi are currently unbeaten and flying high in second place in Serie A, so a victory here would see them break six points clear of Inter in the table.
It’s certainly a tempting prospect for Roberto De Zerbi, who is still missing Francesco Caputo, Gregoire Defrel and Lukas Haraslin, but can count on Berardi, Filip Djuricic and Boga fanning out behind Italy Under-21 international Giacomo Raspadori.
Manuel Locatelli pulls the midfield strings with impressive Maxime Lopez.
Inter have had a rough few days with their 2-0 home Champions League defeat against Real Madrid all but sealing their elimination.
Arturo Vidal was sent off for dissent in that midweek game, but he is again in the starting XI here.
Marcelo Brozovic had been seemingly cleared of COVID, but yesterday’s test came back today as ‘weak positive,’ so he is out again.
Romelu Lukaku is rested in favour of Alexis Sanchez with Lautaro Martinez, while Aleksandar Kolarov, Andrea Pinamonti, Radja Nainggolan and Matias Vecino are out of action.
Sassuolo: Consigli; Toljan, Chiriches, Ferrari, Rogerio; M Lopez, Locatelli; Berardi, Djuricic, Boga; Raspadori
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Vidal, Gagliardini, Perisic; Lautaro Martinez, Alexis Sanchez