Inter are at the Champions League last chance saloon, so Romelu Lukaku, Lautaro Martinez and Marcelo Brozovic start against group leaders Borussia Monchengladbach.
It kicks off in Germany at 20.00 GMT, you can follow all the build-up and action as it happens from this game and Atalanta-Midtjylland on the LIVEBLOG.
The Nerazzurri are practically out of the running for a Champions League knockout place and risk crashing out of Europe altogether, as they go into today in fourth place on just two points.
Shakhtar Donetsk on four host Real Madrid with seven points in the earlier kick-off, and unbeaten Borussia Monchengladbach are on top with eight.
Gladbach need just one point from their last two games to be sure of qualification for the Round of 16.
Arturo Vidal is suspended, with Radja Nainggolan, Aleksandar Kolarov, Matias Vecino and Andrea Pinamonti injured, but the good news is that Brozovic finally returns after testing negative for COVID-19.
Lukaku was rested at the weekend for a 3-0 Serie A win away to Sassuolo, but is back alongside Lautaro Martinez, while Matteo Darmian is preferred to Achraf Hakimi as a more defensive option.
Borussia Monchengladbach must do without Ramy Bensebaini, Jonas Hofman and Nico Elvedi, but the attack is their real strength, with Marcus Thuram and Alassane Plea bringing a French flair to the front line.
So does Valentino Lazaro, who is on loan from Inter.
Borussia Monchengladbach: Sommer; Lainer, Ginter, Jantschke, Wendt; Kramer, Neuhaus; Lazaro, Stindl, Thuram; Plea
BMG bench: Sippel, Grun, M Lang, Herrmann, Zakaria, Wolf, Beyer, Traore, Benes, Embolo, Poulsen
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Gagliardini, Young; R Lukaku, Lautaro Martinez
Inter bench: Stankovic, Radu, Hakimi, Alexis Sanchez, Sensi, Ranocchia, Perisic, Eriksen, D’Ambrosio
Ref: Makkelie (NED)