Italy will face Spain in the Nations League semi-final on October 6 at San Siro, while Belgium take on France on October 7.
The draw was held this afternoon in Nyon and the tournament will be held in Italy from October 6-10, 2021.
The Azzurri qualified by topping their group ahead of Poland, the Netherlands and Bosnia-Herzegovina.
This is the second edition of the Nations League Final Four, as Portugal won in 2019.
Italy open the competition against Spain at San Siro, also known as the Stadio Giuseppe Meazza, on October 6.
Belgium face France in the other semi-final, played on October 7 at the Allianz Juventus Stadium in Turin.
The third place play-off and the final are both on October 10.