Roma and Young Boys go head-to-head for the top spot in their Europa League group, but already qualified for the Round of 32.
The Giallorossi rest Edin Dzeko, Henrikh Mhitaryan, Leonardo Pellegrini and Leonardo Spinazzola, while Marash Kumbulla is back on the bench after his COVID all-clear.
Bryan Cristante is again used as a centre-back, but youth team product Riccardo Calafiori gets a start on the left wing.
Carles Perez and Pedro Rodriguez support Borja Mayoral in a very Spanish attack.
Roma are top of the group on 10 points, with Young Boys on seven, and Cluj follow with four.
Roma: Pau Lopez; Ibanez, Cristante, Juan Jesus; Bruno Peres, Villar, Diawara, Calafiori; Carles Perez, Pedro; Borja Mayoral
Roma bench: Berti, Mirante, Karsdorp, Pellegrini, Dzeko, Fazio, Kumbulla, Spinazzola, Bove, Ciervo, Milanese, Mkhitaryan
Young Boys: Von Ballmoos; Hefti, Camara, Zesiger, Lefort; Rieder, Aebischer, Garcia; Fassnacht, Nsame, Ngamaleu
Young Boys bench: Neuenschwander, Faivre, Sierro, Sulejmani, Gaudino, Burgy, Elia, Siebatcheu, Mambimbi, Maier, Maceiras
Ref: Jovic (CRO)