Roma look to Lorenzo Pellegrini and Henrikh Mkhitaryan to support Edin Dzeko, with Chris Smalling returning in defence, but Torino drop Salvatore Sirigu and several other veterans.
It kicks off at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi are seeking a third consecutive victory, a result that would put them in joint third place with Juventus on 24 points, just four off leaders Milan.
With Atalanta coming up at the weekend, there were reports that Roma would rest Mkhitaryan, but instead the Armenian does start with Lorenzo Pellegrini in a more advanced role.
Even though Pedro Rodriguez is back from suspension, he is still benched.
Bryan Cristante is suspended, with Davide Santon injured, so Chris Smalling gets his first Serie A start since November 8 in the back three.
Torino are in crisis and sit bottom of the table alongside Crotone with just six points from 11 rounds.
President Urbano Cairo confirmed his faith in coach Marco Giampaolo, who makes radical changes this evening, starting from the net.
Salvatore Sirigu is sensationally dropped following tension with the tactician, as Vanja Milinkovic-Savic – younger brother of Lazio star Sergej – is given his first Serie A start since playing for SPAL in November 2018.
That’s not the only veteran shoved to the bench, as also dropped are Armando Izzo, Tomas Rincon, Ricardo Rodriguez, Cristian Ansaldi and Nicolas Nkoulou.
Instead, 21-year-old Alessandro Buongiorno makes his first Serie A start, having previously played just eight minutes in April 2018.
Nicola Murru, Vincenzo Millico and Simone Verdi are all out of action, with Simone Zaza not fully fit, so Sasa Lukic acts as support for Andrea Belotti.
Roma: Pau Lopez; Mancini, Smalling, Ibanez; Bruno Peres, Veretout, Villar, Spinazzola; Pellegrini, Mkhitaryan; Dzeko
Torino: V Milinkovic-Savic; Buongiorno, Bremer, Lyanco; Singo, Gojak, Meite, Linetty, Vojvoda; Lukic; Belotti