Inter saw their run of eight consecutive Serie A victories ended by Sampdoria and two former Nerazzurri players.
Alexis Sanchez had the opportunity to put the visitors in front, but saw his penalty saved by Emil Audero, with Ashley Young firing the rebound onto the woodwork.
Instead, Antonio Candreva converted from the spot for a Nicolò Barella handling offence and Keita Balde Diao struck after sensational work from Mikkel Damsgaard.
Inter saw their run of eight consecutive Serie A victories ended by Sampdoria and two former Nerazzurri players.
Alexis Sanchez had the opportunity to put the visitors in front, but saw his penalty saved by Emil Audero, with Ashley Young firing the rebound onto the woodwork.
Instead, Antonio Candreva converted from the spot for a Nicolò Barella handling offence and Keita Balde Diao struck after sensational work from Mikkel Damsgaard.
Stefan de Vrij’s header got one back for Inter, but Romelu Lukaku and Lautaro Martinez were denied by Audero.