Duvan Zapata and Josip Ilicic lead the way for Atalanta against mid-table surprise outfit Benevento in what should be a very entertaining clash.
It kicks off at the Stadio Vigorito at 14.00 GMT.
La Dea have started 2021 in spectacular fashion, sweeping Sassuolo and Parma aside with eight goals scored and one conceded.
Papu Gomez is still frozen out following his dispute with coach Gian Piero Gasperini, with Mario Pasalic still out injured.
After two games in the starting XI, Luis Muriel returns to the bench for Duvan Zapata, with Josip Ilicic and Matteo Pessina in support.
Benevento are in the top half of the table with 21 points, a remarkable tally for a side newly-promoted from Serie B.
Coach Pippo Inzaghi must do without Luca Caldirola, Iago Falque, Gaetano Letizia, Alessandro Tuia and Gabriele Moncini.
Christian Maggio is back in the starting XI after injury, but Marco Sau is preferred to Gianluca Caprari and Roberto Insigne, joining Gianluca Lapadula in attack.
Benevento: Montipò; Maggio, Foulon, Glik, Barba; Dabo, Schiattarella, Ionita; Improta, Sau; Lapadula
Atalanta: Gollini; Toloi, Romero, Palomino; Hateboer, De Roon, Freuler, Gosens; Pessina; Ilicic, Duvan Zapata