Mattia Perin, Goran Pandev and Cristian Zapata are out of the Genoa squad to face Juventus in the Coppa Italia, but Gianluca Scamacca could play.
The Round of 16 tie kicks off in Turin on Wednesday at 19.45 GMT.
Zapata is still out injured, but Pandev and Juventus-owned goalkeeper Perin are simply not included in Davide Ballardini’s squad.
Luca Pellegrini is also left out, as he is expected to leave Genoa in the January transfer window, but Marko Pjaca can face his parent club.
So could Nicolò Rovella, who had his Juventus medical on Monday, and will remain on loan at Genoa for 18 months.
Scamacca has been heavily linked with a transfer to Juve as well, but he is expected to start tomorrow.
Genoa squad for Juventus: Paleari, Zima, Marchetti; Bani, Criscito, Czyborra, Ghiglione, Goldaniga, Masiello, Dumbravanu; Badelj, Caso, Eyango, Melegoni, Lerager, Radovanovic, Rovella, Zajc; Destro, Males, Parigini, Pjaca, Scamacca, Shomurodov