Juventus use Alvaro Morata and Dejan Kulusevski upfront in the Coppa Italia Round of 16 tie against Gianluca Scamacca’s Genoa.
It kicks off at 19.45 GMT in Turin and the winners will go on to face Sassuolo or Spezia in the quarter-final.
This is a one-off game, to be decided after 90 minutes, extra time or even penalties.
Paulo Dybala is out injured, with Matthijs de Ligt, Alex Sandro and Juan Cuadrado still COVID-19 positive.
Cristiano Ronaldo is rested, so Morata returns for his first start since the muscular injury, partnering Kulusevski, with Federico Bernardeschi and 20-year-old Brazilian Wesley as wing-backs.
It is the first appearance in a Juve jersey for Wesley, nicknamed Gasolina, who was signed from Hellas Verona a year ago.
There are changes in defence too, as Gigi Buffon and Giorgio Chiellini start with Radu Dragusin, who turns 19 next month.
Genoa have been revitalised since coach Davide Ballardini took over from Rolando Maran, his fourth different career stint at the club.
Goran Pandev, Luca Pellegrini, Vittorio Parigini, Davide Biraschi, Cristian Zapata and Francesco Cassata are injured, with Mattia Perin, Stefano Sturaro, Davide Zappacosta and Valon Behrami rested.
Scamacca starts upfront, on loan from Sassuolo and reportedly close to joining Juventus in January.
He is alongside Marko Pjaca, who is on loan from Juve.
Juventus: Buffon; Demiral, Dragusin, Chiellini, Bernardeschi; Wesley, Arthur, Bentancur, Portanova; Morata, Kulusevski
Juventus bench: Szczesny, Pinsoglio, Danilo, Bonucci, Frabotta, Capellini, Ramsey, Rabiot, Ranocchia, Ronaldo, Rafia, Felix Correia
Genoa: Paleari; Goldaniga, Bani, Dumbravanu; Ghiglione, Lerager, Rovella, Melegoni, Czyborra; Pjaca, Scamacca
Genoa bench: Marchetti, Zima, Criscito, Zajc, Radovanovic, Destro, Caso, Badelj, Masiello, Shomurodov, Males, Eboua Ebongue