Luis Muriel, Ruslan Malinovskyi and Aleksei Miranchuk lead Atalanta in the Coppa Italia quarter-final with Lazio’s Andreas Pereira and Sergej Milinkovic-Savic.
It kicks off at 16.45 GMT, you can follow the build-up and action as it happens from this game and Juventus-SPAL on the LIVEBLOG.
The tie will be decided after 90 minutes, extra time or even penalties.
The winners of this particularly quarter-final go on to face either Napoli or Spezia in the two-legged semi-final.
Curiously, Atalanta and Lazio will meet again on Sunday afternoon here in Serie A, so some squad rotation was always going to be expected.
Muriel was rested at the weekend, so he leads the way with Ruslan Malinovskyi and Aleksei Miranchuk.
Hans Hateboer and Mario Pasalic are injured, but January signing Joakim Maehle gets the chance to start.
Lazio are without Felipe Caicedo, Luis Alberto and Luiz Felipe, while Lucas Leiva is suspended in the Coppa Italia.
With Ciro Immobile and Manuel Lazzari rested for the weekend, Vedat Muriqi takes the lead upfront with Pereira and Sergej Milinkovic-Savic.
Muriqi thought he’d scored his debut Lazio goal in the Round of 16 win over Parma, but it was credited as an own goal because it came off the ‘keeper.
Atalanta: Gollini; Djimsiti, Romero, Palomino; Maehle, Freuler, Pessina, Gosens; Malinovskyi, Miranchuk; Muriel
Lazio: Reina; Patric, Hoedt, Acerbi; Marusic, Milinkovic-Savic, Escalante, Akpa Akpro, Fares; Pereira, Muriqi