Roma have Lorenzo Pellegrini back, but again leave Edin Dzeko on the bench as they host a revamped Udinese with Gerard Deulofeu and Rodrigo De Paul.
It kicks off at the Stadio Olimpico at 11.30 GMT.
The Giallorossi were caught in fourth place last week by Lazio and have now been leapfrogged by Napoli, who beat Juventus 1-0 on Saturday.
The pressure is on, yet coach Paulo Fonseca continues to leave Dzeko on the bench following their training ground row last month.
Borja Mayoral leads the attack with Henrikh Mkhitaryan and Pellegrini, the latter returning from suspension, while Chris Smalling and Marash Kumbulla have injury concerns, so Bryan Cristante drops into defence.
Udinese are fresh from a surprising 2-0 victory over Hellas Verona, even more remarkable since Rodrigo De Paul was suspended for that game.
The Argentina international is back in business with Deulofeu and January signing Fernando Llorente.
Roberto Pereyra has joined Fernando Forestieri, Mato Jajalo and Ignacio Pussetto on the treatment table.
Udinese have kept three consecutive Serie A clean sheets, including a 0-0 with Inter, and won this fixture 2-0 in July 2020.
Roma: Pau Lopez; Mancini, Cristante, Ibanez; Karsdorp, Villar, Veretout, Spinazzola; Pellegrini, Mkhitaryan; Mayoral
Udinese: Musso; Bonifazi, Nuytinck, Samir; Stryger Larsen, De Paul, Walace, Arslan, Zeegelaar; Deulofeu, Llorente