Mario Mandzukic seems set to start up front when Milan visit Red Star Belgrade in the Europa League, with Pierre Kalulu at right in defence.
The match kicks off at 17.55 UK time.
Milan are looking to bounce back from the 2-0 defeat to Spezia in Serie A last weekend but coach Stefano Pioli seems set to rest some of his usual starters.
Red Star coach and former Inter player Dejan Stankovic has two Italians in the squad, but neither Diego Falcinelli nor Filippo Falco are expected to start.
With the Derby della Madonnina looming, Pioli will make big changes to the line-up, with Kalulu and Fikayo Tomori set to start in defence.
Captain Alessio Romagnoli and Theo Hernandez will most likely complete the back-four.
Soualiho Meite is expected to start in the middle, with Sandro Tonali and Ismael Bennacer fighting for the second position in the 4-2-3-1 formation.
Samu Castillejo, Rade Krunic and Ante Rebic could start in the attacking trident behind Mandzukic.
Red Star (probable): Borjan; Gajic, Pankov, Milunovic, Rodic; Petrovic, Sanogo; El Fardou, Ivanic, Gavric; Pavkov
Milan (probable): G. Donnarumma; Kalulu, Tomori, Romagnoli, Theo; Meite, Bennacer; Castillejo, Krunic, Rebic; Mandzukic
Referee: Sidiropoulos (GRE)