Fabian Ruiz seems set for a return to the starting line-up for Napoli, who travel to Granada without several key players.
The match kicks off at 20.00 UK time.
Gennaro Gattuso is not going through an easy moment with the Partenopei, as they travel to Spain with 14 first-team players and six from the youth squad.
The Partenopei’s starting line-up is affected by the host of absentees, but the same goes for Granada coach Diego Martinez.
Former Roma attacker Gonalons seems set to start for the home side, who are without seven injured players, including Roberto Soldado.
Napoli are without 10 players and the 4-2-3-1 more or less picks itself and Eljif Elmas seems set to start with Matteo Politano and Lorenzo Insigne in an attacking trident behind Victor Osimhen.
David Ospina is injured, meaning Alex Meret doesn’t have competition for the position between the sticks, behind Giovanni Di Lorenzo, Amir Rrahmano, Nikola Maksimovic and Mario Rui.
Tiemoue Bakayoko could get some rest, as Stanislav Lobotka and Fabian Ruiz seem set to start in the middle.
Granada (probable): Silva; Duarte, Vallejo, Sanchez; Foulquier, Gonalons, Herrera, Neva; Machis, Molina, Kenedy
Napoli (probable): Meret; Di Lorenzo, Rrahmani, Maksimovic, Mario Rui; Fabian Ruiz, Lobotka; Politano, Elmas, Insigne; Osimhen
Referee: Karasev (RUS)