Gennaro Gattuso has precious few options available, as Napoli made the Europa League trip to Granada with only 12 senior outfield players.
It kicks off at the Estadio Municipal Nuevo Los Carmenes at 20.00 GMT.
The Partenopei are fresh from a huge victory over Juventus, but it even further depleted their already thin squad, with new injuries for Hirving Lozano, Andrea Petagna and David Ospina.
It leaves just 12 senior outfield players making the journey, as Kalidou Koulibaly, Kostas Manolas, Dries Mertens, Elseid Hysaj, Diego Demme and Faouzi Ghoulam are among the other absentees.
Inevitably then, Lorenzo Insigne and Victor Osimhen cannot rest for Sunday’s Atalanta clash, starting with Matteo Politano and Eljif Elmas.
Fabian Ruiz makes his first start since early January following COVID-19.
Granada were the surprise outfit in Spain last season, going straight from promotion to seventh place and their first ever Europa League participation.
They’ve got a few absentees too, such as long-term injuries Neyder Lozano and Quini, who are joined on the treatment table by Luis Milla, hitman Roberto Soldado, Luis Suarez, German and Angel Montoro.
There’s room for ex-Roma flop Maxime Gonalons, while former Udinese man Darwin Machis and Chelsea-owned Kenedy support 38-year-old Jorge Molina.
Granada: Rui Silva; Foulquier, Duarte, Vallejo, Neva; Gonalons, Herrera; Machis, Montoro, Kenedy; Molina
Granada bench: Banacloche, Fabrega, Nehuen Perez, German, Brice, Antonio Puertas, Diaz Victor, Alberto Soro, Ruiz Sanchez
Napoli: Meret, Di Lorenzo, Rrahmani, Maksimovic, Mario Rui; Fabian Ruiz, Lobotka; Politano, Elmas, Insigne; Osimhen
Napoli bench: Contini, Idasiak, Zedadka, Bakayoko, Zielinski, Costanzo, D’Agostino, Cioffi, Labriola
Ref: Karasev (RUS)