Tobias Stieler has been appointed for Atalanta-Real Madrid, while Orel Grinfeld will oversee Lazio-Bayern Munich.
The UEFA Referees Commission has named the referees for the upcoming Champions League matches.
Both Serie A sides play the first leg of the Champions League last 16 stage this week.
Lazio host Bayern Munich at the Stadio Olimpico on Tuesday, Atalanta play at the Gewiss Stadium against the Merengues on the following day.
Ref: Orel Grinfeld
Assistants: Roy Hassan and Idan Yarkoni
VAR: Juan Martínez Munuera
Fourth official: Gal Leibovitz
Ref: Tobias Stieler
Assistants: Christian Gittelmann and Eduard Beitinger
VAR: Avar Harm Osmers
Fourth official: Sandro Schärer