Lazio have Manuel Lazzari back in the line-up and are expected to start with Ciro Immobile and Joaquin Correa up front against Bayern Munich.
The match kicks off at 20.00 UK time, follow the build-up and action as it happens on the Liveblog HERE.
Coach Simone Inzaghi has Lazzari available at right and the winger rested last weekend, as he was suspended in the championship.
The coach is expected to confirm the rest of the XI who beat Sampdoria in Serie A last weekend.
Luiz Felipe and Stefan Radu are out injured and thus Patric, Francesco Acerbi and Mateo Musacchio should play again.
Sergej Milinkovic-Savic, Lucas Leiva and Luis Alberto are set to start in the middle, with Immobile and Correa up front.
Bayern have several players out ahead of the first of two legs in the last 16 of the Champions League, but Robert Lewandowski should be certain in the team.
Hansi Flick arrives without Thomas Müller, Douglas Costa, Benjamin Pavard, Serge Gnabry and Corentin Tolisso.
Lazio (probable): Reina; Patric, Acerbi, Musacchio; Lazzari, Milinkovic, Leiva, Luis Alberto, Marusic; Correa, Immobile
Bayern (probable): Neuer; Sule, Boateng, Hernandez, Davies; Kimmich, Alaba; Sane, Goretzka, Coman; Lewandowski
Referee: Grinfeld (ISR)