Ciro Immobile and Sergej Milinkovic-Savic face off with Robert Lewandowski and Leroy Sane as Lazio host Bayern Munich in the Champions League.
The first leg in the Round of 16 kicks off at the Stadio Olimpico at 20.00 GMT.
This is the first time Lazio have made it to the Champions League final 16 in over 20 years, and their best performances of the group stage were against another German side, Borussia Dortmund.
Simone Inzaghi is without Luiz Felipe and Stefan Radu for some time following surgery, so the options in defence are very limited indeed.
Manuel Lazzari was suspended in Serie A for the win over Sampdoria, so he returns with Adam Marusic on the other flank, Milinkovic-Savic, Lucas Leiva and Luis Alberto in midfield.
Joaquin Correa is the partner for Immobile, who gets to face Lewandowski after beating him to the Golden Shoe award as Europe’s top scorer last season.
Wesley Hoedt and Jean-Daniel Akpa-Akpro have to be careful, as they are a booking away from suspension.
Bayern Munich are the top club in the world right now, having won the Champions League and the Club World Cup in 2020.
That latter tournament has taken some toll on their squad, as they’ve stuttered in the Bundesliga lately with a comeback to hold Arminia Bielefeld and this weekend’s 3-2 defeat to Eintracht Frankfurt.
Thomas Muller, Douglas Costa, Benjamin Pavard, Serge Gnabry and Corentin Tolisso are all out of action.
Niklas Süle is back from injury and starting at right-back, but Jamal Musiala is a surprise pick, meaning David Alaba is again used in defence.
The pacey Leroy Sane and ex-Juventus man Kingsley Coman support Leon Goretzka and Lewandowski.
They have only six players available on the bench, including a goalkeeper.
Bayern Munich are unbeaten in the Champions League since March 13, 2019, a 3-1 home defeat to Liverpool.
Their last away defeat in the tournament was 3-0 at PSG in September 2017, a run of 14 games, plus the three on neutral turf in Lisbon.
Lazio: Reina; Patric, Acerbi, Musacchio; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Marusic; Correa, Immobile
Lazio bench: Strakosha, Alia, Pereira, Hoedt, Parolo, Escalante, Lulic, Caicedo, Cataldi, Akpa-Akpro, Muriqi, Fares
Bayern Munich: Neuer; Süle, Boateng, Alaba, Davies; Kimmich, Goretzka; Sané, Musiala, Coman; Lewandowski
Bayern Munich bench: Hoffmann, Javi Martinez, Choupo-Moting, Sarri, Herandez, Marc Roca
Ref: Grinfeeld (ISR)