Atalanta go all-out attack with Duvan Zapata and Luis Muriel as they host a decimated Real Madrid with Isco in the Champions League Round of 16.
It kicks off at the Gewiss Stadium at 20.00 GMT.
This is only Atalanta’s second Champions League campaign, but they reached the quarter-finals last time and were minutes away from eliminating PSG.
On the other hand, record winners Real Madrid haven’t progressed past the last 16 in two seasons and come to Bergamo amid an injury crisis.
Among the absentees are Sergio Ramos, Karim Benzema, Eden Hazard, Dani Carvajal, Eder Militao, Marcelo, Alvaro Odriozola, Federico Valverde and Rodrygo.
The only player out of action for Atalanta is Hans Hateboer, while Josip Ilicic is benched and Papu Gomez left in January for Sevilla.
Duvan Zapata and Luis Muriel start together in an all-Colombian front two, supported by Matteo Pessina, with Joakim Maehle and Robin Gosens on the flanks.
Real Madrid’s choices are limited, but there is still a surprise, as Isco gets a rare start rather than Mariano Diaz, flanked by Marco Asensio and Vinicius Junior.
Isco has started just three Liga matches this season and played 13 minutes in the Champions League, but it looks as if he'll be used as a False 9.
The midfield is likely to be the key to this game, with veterans Luka Modric, Casemiro and Toni Kroos.
Atalanta: Gollini; Toloi, Romero, Djimsiti; Maehle, De Roon, Freuler, Gosens; Pessina; Muriel, Zapata
Atalanta bench: Rossi, Sportiello, Sutalo, Palomino, Lammers, Caldara, Malinovskyi, Ruggeri, Miranchuk, Ilicic, Pasalic
Real Madrid: Courtois; Lucas Vazquez, Varane, Nacho, Mendy; Modric, Casemiro, Kroos; Asensio, Isco, Vinicius
Real Madrid bench: Lunin, Altube, Mariano Diaz, Arribas, Blanco, Chust, Hugo Duro, Miguel
Ref: Stieler (GER)