Lazio must put their Champions League heartache behind them and focus on snatching a top four finish, so no squad rotation as they visit Bologna.
It kicks off at the Stadio Dall’Ara at 17.00 GMT.
Simone Inzaghi’s men are still smarting from the 4-1 home defeat to Bayern Munich on Tuesday, especially as three of the goals were gifted by defensive errors.
With Luiz Felipe and Stefan Radu still out injured, the same problems remain, with only limited options at the back.
Gonzalo Escalante is suspended, so there is also minimal opportunity for squad rotation elsewhere, as Sergej Milinkovic-Savic, Luis Alberto and Ciro Immobile again start with Joaquin Correa.
Bologna have Aaron Hickey suspended following last week’s early red card, plus Takehiro Tomiyasu, Andri Baldursson, Gary Medel, Federico Santander and Paolo Faragò injured.
Mitchell Dijks had been expected to start, but he's not even on the bench due to an adductor issue, so Ibrahima Mbaye plays at left-back.
Riccardo Orsolini gets the nod rather than Andreas Skov Olsen, with Roberto Soriano and Nicola Sansone supporting Musa Barrow.
Bologna: Skorupski; De Silvestri, Danilo, Soumaoro, Mbaye; Svanberg, Dominguez; Orsolini, Soriano, Sansone; Barrow
Lazio: Reina; Patric, Hoedt, Acerbi; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Marusic; Immobile, Correa