Luis Muriel leads the way for Atalanta with Mario Pasalic and Ruslan Malinovskyi, while Sampdoria count on Valerio Verre and Mikkel Damsgaard.
It kicks off at 11.30 GMT, you can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
Gian Piero Gasperini is still fuming after the controversial 1-0 Champions League defeat to Real Madrid on Wednesday, which saw Remo Freuler very harshly sent off just 17 minutes in.
Duvan Zapata went off with a thigh injury during that game and is out here, along with Hans Hateboer, Sam Lammers and suspended Berat Djimsiti.
Therefore, Jose Luis Palomino steps into defence, with Mario Pasalic and Ruslan Malinovskyi supporting Muriel.
Josip Ilicic was introduced as a substitute against Real Madrid and hauled off again, so he’ll need to earn his next opportunity.
Gasperini is sitting out a touchline ban in the stands following his dismissal last week.
Sampdoria have to do without suspended Adrien Silva, while Ernesto Torregrossa and Omar Colley are on the treatment table.
Claudio Ranieri opts to rotate the squad to prepare for the crucial midweek Derby della Lanterna against Genoa, so Antonino La Gumina is supported by Mikkel Damsgaard and Valerio Verre.
Sampdoria: Audero; Bereszynski, Ferrari, Yoshida, Augello; Damsgaard, Thorsby, Ekdal, Jankto; Verre; La Gumina
Atalanta: Sportiello; Toloi, Palomino, Romero; Maehle, De Roon, Freuler, Gosens; Pasalic, Malinovskyi; Muriel