Dries Mertens returns to the starting XI, as Napoli take on Benevento in both a local derby and the battle of the Insigne brothers.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
Gennaro Gattuso remains under intense pressure after crashing out of the Europa League against Granada, but the injury crisis is just beginning to ease a little bit.
Mertens is back in the starting XI and that represents a huge boost, especially with Victor Osimhen, Hirving Lozano and Andrea Petagna still out of action.
Diego Demme and Elseid Hysaj return to the squad too, but Kostas Manolas remains on the treatment table.
Mertens leads the way with support from Lorenzo Insigne, Matteo Politano and Piotr Zielinski, while Faouzi Ghoulam gets the nod at left-back.
This is a local Campania Derby and Benevento go into it without suspended Kamil Glik and injured Iago Falque, while coach Pippo Inzaghi is sitting out a touchline ban.
Roberto Insigne, Lorenzo’s little brother, is initially on the bench, as Gianluca Caprari, Artur Ionita and Nicolas Viola support Gianluca Lapadula.
Despite going down to 10 men last week, Benevento were still able to hold Roma to a rare 0-0 draw.
They’ve got Argentine striker Adolfo Gaich on the bench and waiting to make his impact on Serie A.
Napoli: Meret, Di Lorenzo, Rrahmani, Koulibaly, Ghoulam, Fabian, Bakayoko, Zielinski, Politano, Mertens, Insigne.
Benevento: Montipò; Depaoli, Tuia, Barba, Foulon; Viola, Schiattarella, Hetemaj; Caprari, Ionita; Lapadula.