Roma have a complete reshuffle with Daniele De Rossi returning, Patrik Schick and Alessandro Florenzi supporting Edin Dzeko, while Milan rely on Krzysztof Piatek.
It kicks off at the Stadio Olimpico at 19.30 GMT.
You can follow all the action as it happens from today’s five Serie A games on the LIVEBLOG.
There is only one point separating these teams in the battle for fourth place, and with it Champions League football.
Roma have a complete reshuffle with Daniele De Rossi returning, Patrik Schick and Alessandro Florenzi supporting Edin Dzeko, while Milan rely on Krzysztof Piatek.
It kicks off at the Stadio Olimpico at 19.30 GMT.
You can follow all the action as it happens from today’s five Serie A games on the LIVEBLOG.
There is only one point separating these teams in the battle for fourth place, and with it Champions League football.
Eusebio Di Francesco is under immense pressure after a 7-1 Coppa Italia quarter-final defeat to Fiorentina on Wednesday evening, as the team bus was greeted home by eggs, bottles and other objects.
He has more problems to deal with, as the entire first choice midfield of Bryan Cristante and Steven Nzonzi is suspended, with Cengiz Under, Diego Perotti and Juan Jesus injured.
There were reports of a move to 4-3-3, but instead it’s a change of personnel in much the same tactical system, with Schick, Zaniolo and Alessandro Florenzi lining up behind Edin Dzeko.
Florenzi usually plays on the right flank, but is switched to the left, benching ex-Milan man Stephan El Shaarawy.
Daniele De Rossi gets his first start in three months due to recurring knee problems and Lorenzo Pellegrini drops into a deeper role.
There are no doubts in the Milan XI after their impressive 2-0 Coppa Italia victory over Napoli on Tuesday.
That was January signing Piatek’s first start in a Rossoneri jersey and he bagged a brace within 27 minutes.
He pushes Patrick Cutrone on the bench, with support from Suso and Hakan Calhanoglu, while Lucas Paquetá continues his trend of starting every match since his €35m move from Flamengo.
Mattia Caldara, Lucas Biglia, Jack Bonaventura, Cristian Zapata and Pepe Reina are still injured.
Milan have won their last two Serie A games against Roma, but haven’t made it three on the bounce since 1996.
Roma: Olsen; Karsdorp, Manolas, Fazio, Kolarov; De Rossi, Lorenzo Pellegrini; Schick, Zaniolo, Florenzi; Dzeko
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Paquetá; Suso, Piatek, Calhanoglu