Napoli rely on Dries Mertens and Lorenzo Insigne against Domenico Berardi’s attack-minded Sassuolo, but Kalidou Koulibaly is suspended.
It kicks off at 17.30 GMT, you can follow all the build-up and action as it happens from today’s seven Serie A games on the LIVEBLOG.
Gennaro Gattuso managed to stop the rot and demands for his dismissal with last week’s 2-0 win over Benevento, but need more than that to recover from the Europa League exit to Granada.
The injury crisis remains intensive, although Mertens made his comeback last week and promptly scored.
He’s needed more than ever now, as Victor Osimhen, Hirving Lozano and Andrea Petagna are all out of action.
It’s more of a 4-3-3 with Mertens flanked by Lorenzo Insigne and ex-Sassuolo man Matteo Politano, moving Piotr Zielinski into midfield with returning Diego Demme.
Koulibaly is suspended, with Kostas Manolas not yet fit to start, so Amir Rrahmani and Nikola Maksimovic fill in.
Sassuolo have struggled to keep up with their early season form, yet remain in joint eighth place with Hellas Verona.
Jeremie Boga, Medhi Bourabia, Vlad Chiriches and Filippo Romagna are still out injured, so Domenico Berardi and Francesco Caputo are the star names, along with midfielder Manuel Locatelli.
It's a very attack-minded line-up, with Maxime Lopez in midfield and Gregoire Defrel part of the front four.
The Neroverdi won away to Napoli earlier this season, so Gattuso’s men are out for revenge.
Sassuolo: Consigli; Muldur, Marlon, Ferrari, Rogerio; Lopez, Locatelli; Berardi, Defrel, Djuricic; Caputo
Napoli: Meret; Di Lorenzo, Rrahmani, Maksimovic, Hysaj; Fabian Ruiz, Demme, Zielinski; Politano, Mertens, L Insigne