Fiorentina bring Giovanni Simeone back into the starting XI and Gerson faces his old club, as Roma field 19-year-old Nicolò Zaniolo.
It kicks off at 17.00 GMT, you can follow the build-up and action from this game, Inter–Genoa and Juventus–Cagliari on the LIVEBLOG.
This is a head-to-head for European places and they are locked together on 15 points, along with Sampdoria and Sassuolo.
Fiorentina bring Giovanni Simeone back into the starting XI and Gerson faces his old club, as Roma field 19-year-old Nicolò Zaniolo.
It kicks off at 17.00 GMT, you can follow the build-up and action from this game, Inter-Genoa and Juventus-Cagliari on the LIVEBLOG.
This is a head-to-head for European places and they are locked together on 15 points, along with Sampdoria and Sassuolo.
Kevin Mirallas gets the nod with Federico Chiesa and Simeone.
Cholito has much to prove, because he was sensationally dropped last week due to poor form.
It’s also a special match for Gerson, the former Roma flop now at Fiorentina.
The Giallorossi are forced to do without injured Daniele De Rossi, Luca Pellegrini, Diego Perotti and Rick Karsdorp for the trip to the Stadio Franchi.
Bryan Cristante had been expected to step in, but Italy Under-21 international Zaniolo is given the trequartista role with Cengiz Under and Stephan El Shaarawy, supporting Edin Dzeko.
That means Lorenzo Pellegrini returns to his old position in midfield, at least to begin with.
Kostas Manolas is not 100 per cent fit either, so Juan Jesus comes in.
Fiorentina: Lafont; Milenkovic, Pezzella, Vitor Hugo, Biraghi; Benassi, Veretout, Gerson; Chiesa, Simeone, Mirallas
Fiorentina bench: Brancolini, Dragowski, Laurini, Ceccherini, Norgaard, Pjaca, Dabo, Hancko, Sottil, Edimilson Fernandes, Vlahovic, Diks
Roma: Olsen; Florenzi, Juan Jesus, Fazio, Kolarov; Lo Pellegrini, Nzonzi; Under, Zaniolo, El Shaarawy; Dzeko
Roma bench: Fuzato, Mirante, Cristante, Schick, Marcano, Santon, Coric, Pastore, Kluivert, Manolas
Ref: Banti