Roma have Marash Kumbulla back in defence, with Henrikh Mkhitaryan and Lorenzo Pellegrini supporting Borja Mayoral against Franck Ribery’s Fiorentina.
It kicks off at the Stadio Franchi at 19.45 GMT.
Both teams are coming off painful defeats that dented their confidence and standing, as Roma lost the head-to-head with Milan for Champions League spots, while Fiorentina fell 1-0 at Udinese.
The pressure is building on Paulo Fonseca, who admitted they have a real problem against the bigger clubs, but there is some good news for the Giallorossi.
Kumbulla is back in defence, although Roger Ibanez, Edin Dzeko, Davide Santon, Riccardo Calafiori and Nicolò Zaniolo are out of action.
Juan Jesus also pulled out after he came into contact with someone who tested positive for COVID-19, so has returned to Rome in order to go into isolation.
Fonseca had already made clear he considered Borja Mayoral his first choice striker anyway, supported by Pellegrini and Mkhitaryan.
Fiorentina are missing Giacomo Bonaventura and Christian Kouame, while Jose Callejon can’t seem to get a look-in after arriving as a free agent from Napoli.
Ribery is still getting back to full fitness and supports Dusan Vlahovic upfront, with Gaetano Castrovilli pulling the midfield strings.
Roma have failed to find the net in their last three Serie A away matches and could make it four for the first time since March 1985.
Fiorentina: Dragowski; Milenkovic, Pezzella, Martinez Quarta; Venuti, Amrabat, Pulgar, Castrovilli, Igor; Ribery, Vlahovic
Roma: Pau Lopez; Mancini, Cristante, Kumbulla; Bruno Peres, Veretout, Diawara, Spinazzola; Pellegrini, Mkhitaryan; Borja Mayoral