Dries Mertens leads the Napoli attack with Lorenzo Insigne and Matteo Politano, as Victor Osimhen is on the bench, while Bologna look to veteran Rodrigo Palacio.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
Gennaro Gattuso remains under pressure after a chaotic 3-3 draw with Sassuolo midweek, which saw Lorenzo Insigne furiously vent his frustration at the last-gasp equaliser.
Kalidou Koulibaly was suspended for that game and returns here, although Hirving Lozano, Andrea Petagna and Tiemoue Bakayoko miss out.
The big news is the return of Osimhen, who has been through the mill this season, between a dislocated shoulder, COVID and being knocked unconscious.
The Nigeria international is however only on the bench, as Mertens leads the way with support from Piotr Zielinski, Insigne and Politano.
Bologna are unpredictable, as they can go from beating Lazio 2-0 to a disappointing 1-0 defeat at Cagliari, frustrating coach Sinisa Mihajlovic.
They are forced into changes here, as Jerdy Schouten is suspended, with Aaron Hickey, Mitchell Dijks, Takehiro Tomiyasu, Andri Baldursson, Federico Santander and Paolo Faragò injured.
Veteran Rodrigo Palacio gets the nod initially rather than Musa Barrow upfront, while Andrea Poli and Andreas Skov Olsen step in, sending Riccardo Orsolini to the bench.
There will be a minute’s silence and Bologna wear black armbands following the death of Mirko Pavinato, who was captain of their Scudetto-winning side in 1964.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Ghoulam; Fabian Ruiz, Demme, Zielinski; Politano, Mertens, L Insigne
Bologna: Skorupski; De Silvestri, Danilo, Soumaoro, Mbaye; Svanberg, Poli; Skov Olsen, Soriano, Sansone; Palacio