Henrikh Mkhitaryan is used as a False 9 against his former club Shakhtar Donetsk, as Roma also look to Lorenzo Pellegrini and Pedro in the Europa League Round of 16.
The first leg kicks off at the Stadio Olimpico at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Manchester United-Milan on the LIVEBLOG.
Henrikh Mkhitaryan is used as a False 9 against his former club Shakhtar Donetsk, as Roma also look to Lorenzo Pellegrini and Pedro in the Europa League Round of 16.
The first leg kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi had a very tricky draw for this stage of the competition, because Shakhtar Donetsk dropped down from the Champions League, where they finished above Inter and beat Real Madrid.
It’s a reunion for Paulo Fonseca and Mkhitaryan, facing their old club, and the Armenian starts upfront as a False 9.
This allows Borja Mayoral to rest, while Edin Dzeko only just resumed training after two weeks out with an adductor strain.
He is supported by Pellegrini and Pedro, with Rick Karsdorp and Leonardo Spinazzola on the wings.
Shakhtar Donetsk line up in their usual 4-3-3 formation with Tete and Taison flanking Junior Moraes.
Alan Patrick and Marlos are names to watch out for in midfield, as this is a very Brazil-heavy team.
They won the Europa League in 2009 and reached the semi-final last season, knocked out by Inter.
Bruno Peres, Rick Karsdorp, Gonzalo Villar and Vitao are all one yellow card away from suspension, with the second leg set for March 18.
Roma: Pau Lopez; Mancini, Cristante, Kumbulla; Karsdorp, Diawara, Villar, Spinazzola; Pellegrini, Pedro; Mkhitaryan
Roma bench: Mirante, Fuzato, Ibanez, Smalling, Dzeko, Santon, Mayoral, Carles Perez, Bruno Peres, Calafiori, El Shaarawy
Shakhtar Donetsk: Trubin; Dodo, Vitao, Matviyenko, Ismaily; Marlos, Maycon, Alan Patrick; Tete, Junior Moraes, Taison
Shakhtar Donetsk bench: Shevchenko, Pyatov, Kryvstov, Marcos Antonio, Dentinho, Korniienko, Solomon, Bolbat, V’Yunnik, Sudakov, Konoplyanka, Bondar
Ref: Dias (POR)