Roma will face Ajax in the Europa League quarter-finals. The first leg is in Amsterdam on April 8, the second leg is in Rome the following week.
The Giallorossi eliminated Braga and Shakhtar in the knock-out stages of the competition.
Their next opponent is Ajax. The Lancers were eliminated from the Champions League group at Liverpool, and Atalanta’s hands.
Ajax and Roma only met twice before, in the 2002-03 Champions League second group stage.
The Giallorossi faced an away 2-1 defeat and picked a 1-1 draw at the Stadio Olimpico.
Zlatan Ibrahimovic scored the opener in Amsterdam 19 years ago.
The winner of the fixture will meet the winner of Granada-Manchester United in the semi-finals.