Zlatan Ibrahimovic and Hakan Calhanoglu lead the way for Milan, Alexis Saelemaekers relaunched as a right-back against Fabio Quagliarella and Manolo Gabbiadini’s Sampdoria.
It kicks off at 11.30 UK time (10.30 GMT), you can follow the build-up and action as it happens from today’s 10 Serie A games on the LIVEBLOG.
The Rossoneri are now out of the Europa League and their injury crisis is beginning to ease, so they can focus on keeping the Scudetto race alive.
While Davide Calabria, Alessio Romagnoli, Rafael Leao and Mario Mandzukic are still out of action, Ibrahimovic and Calhanoglu rediscovered their form with goals or assists on international duty.
It was assumed Diogo Dalot or Pierre Kalulu would start at right-back, but instead it’s winger Saelemaekers who is revamped in this role.
With both Saelemaekers and Theo Hernandez focused more on attack than defence, it’s going to be an interesting approach.
Ante Rebic saw his two-match ban for insulting the referee reduced to one on appeal, but he is on the bench.
Ismael Bennacer is a vital midfield presence after months out of action.
Sampdoria miss Albin Ekdal and Ernesto Torregrossa, but Gabbiadini is finally getting some regular playing time after his injury problems, partnering veteran hitman Quagliarella.
Mikkel Damsgaard had a splendid break for international duty with Denmark, as the 20-year-old scored two goals and provided two assists in the 8-0 victory over Moldova.
Milan: G Donnarumma; Saelemaekers, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Castillejo, Calhanoglu, Krunic; Ibrahimovic
Milan bench: A Donnarumma, Tatarusanu, Dalot, Gabbia, Kalulu, Hauge, Meite, Tonali, Rebic
Sampdoria: Audero; Bereszynski, Tonelli, Colley, Augello; Candreva, Thorsby, Silva, Damsgaard; Gabbiadini, Quagliarella
Sampdoria bench: Letica, Ravaglia, Ferrari, Regini, Yoshida, Askildsen, Jankto, Leris, Verre, Keita Balde, La Gumina, Ramirez