Victor Osimhen, Dries Mertens and Lorenzo Insigne lead the way for Napoli against Nwankwo Simy and on-loan Adam Ounas, as Crotone fight for survival.
It kicks off at the Stadio Diego Armando Maradona at 14.00 UK time (13.00 GMT).
The Partenopei are back in the race for the top four, sitting just two points behind Atalanta and Juventus with a game in hand.
That game, to be played in Turin with Juve, is scheduled for Wednesday April 7.
Gennaro Gattuso can finally count on most of his squad after the injury crisis that went on for months, as Osimhen leads the line with Lorenzo Insigne, Mertens and Matteo Politano.
Zielinski had been in doubt after a COVID outbreak in the Poland squad, but following a false positive test, he was given the all-clear.
Nonetheless, with fatigue also a factor, Gattuso decided to rest Zielinski in favour of a new trequartista role for Mertens.
Kalidou Koulibaly is suspended, with Diego Demme and Faouzi Ghoulam injured, so Kostas Manolas returns to the starting XI.
David Ospina hurt his finger in training, so Alex Meret is in goal.
Crotone are practically doomed, but they won’t go down without a fight, putting in some brave and chaotic performances since Serse Cosmi took over.
Arkadiusz Reca is on the treatment tale and Jacopo Petriccione injured, but Osimhen’s fellow Nigeria international Simy is finding his form lately and leads the attack with Ounas, who of course is on loan from Napoli, and therefore eager to make a point here.
Napoli: Meret; Di Lorenzo, Maksimovic, Manolas, Mario Rui; Fabian Ruiz, Bakayoko; Politano, Mertens, L Insigne; Osimhen
Crotone: Cordaz; Djidji, Golemic, Luperto; Rispoli, Messias, Benali, Zanellato, Molina; Ounas, Simy
Ref: Di Martino