Inter should have Stefan de Vrij and Roberto Gagliardini back in the starting line-up, when Sassuolo arrive with a long list of unavailable players.
The match kicks off at 17.45 UK time.
Inter are on a run of nine consecutive wins and could increase their advantage at the top of Serie A with another three points against the Neroverdi.
Antonio Conte must cope without suspended Alessandro Bastoni and Marcelo Brozovic but have De Vrij back in the squad for the recovery of the fixture postponed due to coronavirus.
But coronavirus affects this Serie A Week 28 match again, as Sassuolo are without eight key players and have decided to protect the squad from the internationals having been in contact with other teams’ positive players.
Gagliardini is expected to replace Brozovic in the middle, whilst Lautaro Martinez and Romelu Lukaku seem set to continue up front, with Alexis Sanchez on the bench.
Domenico Berardi, Francesco Caputo, Gregoire Defrel and Mehdi Bourabia are not available due to injuries, whilst Kaan Ayhan is out with coronavirus.
Roberto De Zerbi has confirmed Gian Marco Ferrari, Mert Muldur and Manuel Locatelli are left out again, as they returned from international camps with coronavirus outbreaks.
Sassuolo haven’t lost away to Inter since 2014 and Giacomo Raspadori is expected to start up front when Sassuolo try to stretch their unbeaten run against Inter.
Hamed Traore, Filip Djuricic and Jeremie Boga should start in the attacking trident behind the striker.
Inter (probable): Handanovic; Skriniar, De Vrij, Darmian; Hakimi, Barella, Eriksen, Gagliardini, Young; Lautaro, Lukaku
Sassuolo (probable): Consigli; Toljan, Chiriches, Marlon, Rogerio; Obiang, Lopez; Traore, Djuricic, Boga; Raspadori