Juventus welcome Gigi Buffon back to the starting XI, but not the ‘lockdown party rebels’, while Napoli go with Hirving Lozano, Dries Mertens and Piotr Zielinski.
It kicks off in Turin at 17.45 UK time (16.45 GMT), you can follow all the build-up and action as it happens from this game and Inter-Sassuolo on the LIVEBLOG.
This Week 3 fixture was originally meant to be played on October 4, but cancelled when Napoli were ordered not to travel by the local health authority following COVID cases.
The Partenopei were originally given an automatic 3-0 defeat and docked a point for not sticking to the protocol, but that decision was reversed on appeal and the game rescheduled.
Both clubs are locked together in joint fourth place, so this could be a potentially decisive result in the race for a Champions League spot.
Juve are in crisis after losing to Benevento and only drawing 2-2 with Torino, but Weston McKennie, Arthur and Paulo Dybala all return after they were dropped for the Turin Derby due to breaking lockdown rules with a party at the American’s house.
However, they are not in the starting XI and there are even reports Dybala’s knee pain has flared up again.
Leonardo Bonucci and Federico Bernardeschi are out with COVID-19, but Merih Demiral has recovered and is on the bench.
Buffon returns after his ban for using a blasphemous phrase and is given the gloves after Wojciech Szczesny’s recent errors.
Napoli make big changes from the side that beat Crotone 4-3 on Saturday, including the return of Kalidou Koulibaly from suspension.
Amir Rrahmani is chosen to partner him in defence after costly errors from Nikola Maksimovic and Kostas Manolas.
Diego Demme is back in midfield, with Zielinski, Lozano and Lorenzo Insigne supporting Mertens.
When these teams met in February, Napoli came away with a 1-0 win thanks to an Insigne penalty, having lost the Italian Supercup 2-0 in January.
Juventus: Buffon; Danilo, De Ligt, Chiellini, Alex Sandro; Cuadrado, Bentancur, Rabiot, Chiesa; Morata, Ronaldo
Juventus bench: Szczesny, Pinsoglio, Demiral, Frabotta, Dragusin, Di Pardo, Arthur, McKennie, Fagioli, Ramsey, Kulusevski, Dybala
Napoli: Meret; Di Lorenzo, Rrahmani, Koulibaly, Hysaj; Fabian Ruiz, Demme; Lozano, Zielinski, L Insigne; Mertens
Napoli bench: Contini, Ospina, Bakayoko, Mario Rui, Elmas, Osimhen, Maksimovic, Politano, Petagna, Manolas, Cioffi, Lobotka