Inter are seeking a 10th consecutive Serie A victory in this rescheduled Week 28 tie with Sassuolo, but are forced into some adjustments.
It kicks off at San Siro at 17.45 UK time (16.45 GMT).
This tie was originally scheduled for March 20, but had to be postponed due to a COVID outbreak in the Inter camp involving players and staff.
All of those have now recovered and Samir Handanovic already made his comeback on Saturday in a 1-0 win away to Bologna.
The Nerazzurri have the opportunity to go 11 points clear at the top of the Serie A table, but Antonio Conte does have to make some changes, as Alessandro Bastoni and Marcelo Brozovic are suspended.
Matteo Darmian and Roberto Gagliardini step in, with Stefan de Vrij returning from COVID.
Sassuolo have taken a very cautious approach to Coronavirus, deciding to freeze out Manuel Locatelli, Gian Marco Ferrari and Mert Muldur after an outbreak in their international squads, even though their tests are so far coming back negative.
Kaan Ayhan is positive for COVID, with Francesco Caputo, Domenico Berardi, Gregoire Defrel and Medhi Bourabia injured.
It means Under-21 international Giacomo Raspadori starts again after a 2-2 draw with Roma on Saturday.
Sassuolo have a remarkable record against Inter, unbeaten at San Siro since 2014.
Inter: Handanovic; Skriniar, De Vrij, Darmian; Hakimi, Barella, Eriksen, Gagliardini, Young; Lautaro Martinez, Lukaku
Inter bench: Padelli, Radu, Alexis Sanchez, Vecino, Sensi, Ranocchia, Vidal, D’Ambrosio, Pinamonti
Sassuolo: Consigli; Toljan, Chiriches, Marlon, Rogerio; Obiang, Lopez; Traore, Djuricic, Boga; Raspadori
Sassuolo bench: Pegolo, Turati, Magnanelli, Peluso, Artioli, Karamoko, Haraslin, Oddei, Piccinini, Saccani, Kyriakopoulos