Atalanta and Juventus go head-to-head for third place, as Duvan Zapata, Luis Muriel and Robin Gosens face Paulo Dybala and Alvaro Morata, but Cristiano Ronaldo misses out.
It kicks off at the Gewiss Stadium in Bergamo at 14.00 UK time (13.00 GMT).
There’s only one point separating these sides in third and fourth going in, and it could be a decisive result in the wider race for the Champions League spots.
The big news on the eve of the game was Cristiano Ronaldo’s flexor injury, which means he hasn’t even made the trip to Bergamo.
Federico Bernardeschi still has COVID, so the only option is to start Dybala with Morata, even though La Joya might not have 90 minutes in his legs.
Danilo has a toe injury and is not fit to start either, so Juan Cuadrado remains at right-back, with Weston McKennie and Federico Chiesa taking the wide midfield roles.
Giorgio Chiellini remains in defence, despite Leonardo Bonucci recovering from COVID.
Atalanta also have a player back after he contracted the Coronavirus on international duty with Italy, as Matteo Pessina returns to the fold.
However, defender Cristian Romero is suspended against his parent club and Hans Hateboer a long-term absentee.
Gian Piero Gasperini retains the recent four-man defence experiment, with Robin Gosens as a left winger and Joakim Maehle at the back, Pessina and Muriel to support Duvan Zapata.
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Maehle, De Roon, Freuler, Gosens; Pessina; Muriel, Duvan Zapata
Atalanta bench: Rossi, Sportiello, Sutalo, Lammers, Caldara, Malinovskyi, Kovalenko, Ruggeri, Miranchuk, Ilicic, Pasalic
Juventus: Szczesny; Cuadrado, De Ligt, Chiellini, Alex Sandro; McKennie, Bentancur, Rabiot, Chiesa; Dybala, Morata
Juventus bench: Buffon, Pinsoglio, Danilo, Bonucci, Demiral, Frabotta, Arthur, Ramsey, Kulusevski, Felix Correia