Lazio could be without Lucas Leiva and Luis Alberto, and Milan seem set to start with Mario Mandzukic in the absence of Zlatan Ibrahimovic.
The match at the Olimpico kicks off at 19.45 UK time.
The big game between the two Champions League hopefuls concludes Serie A Week 33 on Monday night, and Lazio have some problems in midfield.
Simone Inzaghi could have to rest both Lucas Leiva and Luis Alberto against the Rossoneri, as the Brazilian struggles only three days after the defeat to Napoli.
Lazio could be without Lucas Leiva and Luis Alberto, and Milan seem set to start with Mario Mandzukic in the absence of Zlatan Ibrahimovic.
The match at the Olimpico kicks off at 19.45 UK time.
The big game between the two Champions League hopefuls concludes Serie A Week 33 on Monday night, and Lazio have some problems in midfield.
Simone Inzaghi could have to rest both Lucas Leiva and Luis Alberto against the Rossoneri, as the Brazilian struggles only three days after the defeat to Napoli.
The home side are looking to bounce back from the 5-2 defeat to the Partenopei last week and must rely on Danilo Cataldi and Andreas Pereira from the start.
Felipe Caicedo and Gonzalo Escalante should be out too, whilst Adam Marusic continues at in the back-three, with Mohamed Fares out wide.
Joaquin Correa and Ciro Immobile seem ready to start in attack for the Aquile, who face a Milan side without Sweden international Ibrahimovic.
Stefano Pioli could give Mandzukic the go ahead against the Biancocelesti, his first start after playing 37 minutes in the last two games.
His only start for Milan so far came against Red Star in the Europa League. Theo Hernandez still needs to be assessed ahead of today’s game, but the French full-back will be called up.
Fikayo Tomori has struggled with a physical problem in recent days, but should play over Alessio Romagnoli.
Lazio (probable): Reina; Marusic, Acerbi, Radu; Lazzari, Milinkovic-Savic, Cataldi, Pereira, Fares; Correa, Immobile
Milan (probable): G. Donnarumma; Calabria, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Saelemaekers, Calhanoglu, Rebic; Mandzukic
Ref: Orsato