Paulo Dybala partners Cristiano Ronaldo, as the pressure is on Juventus to beat an Udinese side with few remaining forwards.
It kicks off at the Dacia Arena at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
Juve risk not even qualifying for the Champions League and there were even some reports Andrea Pirlo could be sacked if he doesn’t win here today.
Alvaro Morata has a calf problem, with Federico Chiesa and Merih Demiral not even making the trip, so Dybala has to partner Ronaldo upfront.
Udinese goalkeeper Juan Musso is suspended, so Simone Scuffet gets his first Serie A start since October 2018.
A former child star of Calcio considered the ‘new Gigi Buffon’ when making his debut aged 17, his career never quite flourished, with loan spells at Como, Spezia and even in Turkey.
He’s not the only change, because the Friulani have an injury crisis among their forwards, ruling out Jayden Braaf, Ilija Nestorovski, Gerard Deulofeu, Ignacio Pussetto and Gerard Deulofeu.
Fernando Llorente isn’t at full strength either, so ex-Juventus man Roberto Pereyra supports Stefano Okaka.
As always, Rodrigo De Paul is pulling the strings in midfield, having been linked with moves to Inter, Milan and Juventus.
Udinese: Scuffet; Becao, Nuytinck, Bonifazi; N Molina, De Paul, Walace, Arslan, Stryger-Larsen; Pereyra; Okaka
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Alex Sandro; Cuadrado, Bentancur, McKennie, Bernardeschi; Dybala, Ronaldo