It’s the top of the table clash in Turin as Juventus start with Marco Storari, Sebastian Giovinco and Fabio Quagliarella against Napoli’s Edinson Cavani, Goran Pandev and Marek Hamsik.
These two sides are joint Serie A leaders going into the 17.00 UK time kick-off, which you can watch LIVE on your computer.
They already went head-to-head in the Coppa Italia Final in May and the fiery Italian Super Cup in Beijing in August.
Juve have to do without Gianluigi Buffon, Mirko Vucinic, Paolo De Ceglie and Simone Pepe. Buffon picked up a thigh injury on international duty, while Vucinic is debilitated by a bout of flu.
Giovinco has been picked as the partner to Neapolitan Quagliarella, leaving Alessandro Matri on the bench.
Napoli can rely on their Three Tenors, as Cavani is fit to start despite a delayed return journey from Uruguay that means he only had one training session with the club.
Pandev is his strike partner with Hamsik in a slightly deeper role, so Lorenzo Insigne is on the bench after his stunning goal for the Under-21 side this week.
Miguel Angel Britos is the only injury absentee in defence.
Juventus have assistant manager Angelo Alessio back on the bench after his ban in the betting scandal was reduced on appeal, but Antonio Conte is still in the stands.
There are already reports of trouble in the build-up to the game, as a group of Napoli supporters from Parma claim their bus was attacked at a motorway service station.
Juventus: Storari; Barzagli, Bonucci, Chiellini; Lichtsteiner, Marchisio, Pirlo, Vidal, Asamoah; Quagliarella, Giovinco
Juventus bench: Rubinho, Branescu, Lucio, Caceres, Isla, Marrone, Pogba, Padoin, Giaccherini, Bendtner, Matri
Napoli: De Sanctis; Campagnaro, Cannavaro, Gamberini; Maggio, Inler, Behrami, Zuniga; Hamsik; Pandev, Cavani
Napoli bench: Rosati, Grava, Fernandez, Aronica, Uvini, Mesto, Dzemaili, Donadel, Dossena, Insigne, Vargas
See the latest Serie A predictions and betting tips with Eurotips.co.uk