Marco Borriello starts for Genoa in the desperate Derby della Lanterna, but Sampdoria’s Eder failed a fitness test.
Going into this clash, the Rossoblu are bottom of the table with nine points and Samp sit just one ahead of them, so there is a lot more at stake than mere local pride.
Gigi Del Neri takes on his former club, but has lost all four games on the Genoa bench since replacing Gigi De Canio.
Borriello is back in the starting XI after time out with a sprained ankle, but Cristobal Jorquera, Damiano Ferronetti and Anselmo are sidelined.
Ciro Ferrara is hanging by a thread after seven consecutive defeats on the Blucerchiati bench and is forced to completely reshuffle his attack.
Maxi Lopez, Nicola Pozzi and Gaetano Berardi are out of action, while Eder picked up a knock in training and failed a late fitness test.
It means 19-year-old Argentine Mauro Icardi has to lead the strike force in this most high profile of matches.
Sampdoria: Romero; Mustafi, Gastaldello, Rossini, Costa; Munari, Maresca, Obiang, Poli; Krsticic; Icardi
Sampdoria bench: Berni, Falcone, Estigarribia, Renan, Castellini, Tissone, Poulsen, De Silvestri, Soriano, Juan Antonio, Savic, Austoni
Genoa: Frey; Sampirisi, Granqvist, Bovo, Moretti; Jankovic, Tozser, Kucka, Antonelli; Immobile, Borriello,
Genoa bench: Tzorvas, Donnarumma, Rossi, Vargas, Melazzi, Merkel, Seymour, Hallenius, Canini, Said, Bertolacci
See the latest Serie A predictions and betting tips with Eurotips.co.uk