Lazio aim to go top of the table by visiting troubled Palermo at 17.00 GMT, but have to revamp without Miroslav Klose.
The Biancocelesti are in joint second place with Napoli, only three points shy of Serie A leaders Juventus.
Vladimir Petkovic’s men are unbeaten in 14 official games, but visit Sicily without the injured Klose, Abdoullay Konko, Ederson and Marius Stankevicius.
There are also fitness doubts over Alvaro Gonzalez and Andre Dias, so they will not be risked from the start ahead of a Coppa Italia semi-final with Juventus on Tuesday.
Lorik Cana therefore steps into the back three, moving Stefan Radu into a more advanced wide role, while Stefano Mauri supports centre-forward Sergio Floccari.
Palermo are in crisis with one point from the last six rounds, so Coach Gian Piero Gasperini is thought to be up for the sack.
Edgar Barreto sits out a ban with the injured Franco Brienza, Andrea Mantovani and Abel Hernandez.
Gasperini already announced his starting XI in a tense Press conference, fielding a 3-4-3 with Fabrizio Miccoli, Paulo Dybala and Josip Ilicic together.
January signings Salvatore Aronica and Andrea Dossena also start.
Palermo: 1 Ujkani; 25 Von Bergen, 3 Aronica, 29 Garcia; 89 Morganella, 20 Arevalo Rios, 28 Kurtic, 8 Dossena; 27 Ilicic; 9 Dybala, 10 Miccoli
Palermo bench: 99 Benussi, 6 Munoz, 7 Viola, 14 Anselmo, 22 Brichetto, 23 Donati, 24 Malele, 50 Sanseverino, 51 Bollino
Lazio: 22 Marchetti; 20 Biava, 27 Cana, 2 Ciani; 26 Radu, 39 Cavanda, 24 Ledesma, 8 Hernanes, 19 Lulic; 6 Mauri; 99 Floccari
Lazio bench: 1 Bizzarri, 3 Dias, 5 Scaloni, 15 Gonzalez, 18 Kozak, 25 Rozzi, 32 Brocchi, 78 Zauri, 84 Carrizo, 87 Candreva